Association between Metabolic Syndrome and Alcohol Consumption: A Cross-sectional Study
Abstract
Materials and Methods: A cross-sectional study was conducted on 400 participants recruited from the Outpatient Unit of the Family Medicine Department, Faculty of Medicine, Chiang Mai University. Physical examination and blood tests were carried out to evaluate the presence of metabolic syndrome. The drinking patterns were stratified into four levels, which were abstinence, occasional drinking, light–moderate drinking, and heavy drinking (>40 gm/day). The Alcohol Use Disorders Identification Test was used to evaluate the risk of harm from alcohol consumption.
Results: The percentage of current drinkers was 27.3%, and most of them were men (87.2%). Waist circumference, triglyceride levels, and diastolic blood pressure were significantly higher among those with a heavy drinking habit and harmful alcohol use/dependence. High density lipoprotein cholesterol (HDL-C) showed different results. A J-shaped association was found between HDL-C and drinking pattern, but an inverse relationship was indicated with the risk of harm. Metabolic syndrome was found to be significantly associated with heavy drinking (OR=4.4, 95% Confidence Interval (CI) 1.2–15.6, p-value 0.021) and the harmful use/dependent categories (OR=5.0, 95% CI 1.1–23.1, p-value 0.039).
Conclusion: The results suggest that alcohol drinking tends to be associated with an increased risk of metabolic syndrome. This condition should be screened regularly especially in those with heavy drinking or at-risk drinking habits.
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World Health Organization. Global status report on alcohol and health 2014 [monograph on the Internet]. Geneva: WHO; 2014 [cited 2018 Jun 8]. Available from: https://apps.who. int/iris/bitstream/handle/10665/112736/9789240692763_ eng.pdf;jsessionid=88838C3179E9CA89F0BC7FEF9C559FDB? sequence=1
World Health Organization. Global Status Report on Alcohol and Health 2011 [monograph on the Internet]. Geneva: WHO; 2011 [cited 2018 Jun 8]. Available from: https://apps.who. int/iris/bitstream/handle/10665/44499/9789241564151_ eng.pdf?sequence=1
Costanzo S, Di Castelnuovo A, Donati MB, Iacoviello L, de Gaetano G. Alcohol consumption and mortality in patients with cardiovascular disease: a meta-analysis. J Am Coll Cardiol 2010;55:1339-47.
Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G. Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch of Intern Med. 2006;166:2437-45.
Di Castelnuovo A, Rotondo S, Iacoviello L, Donati MB, De Gaetano G. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation 2002;105:2836-44.
Thamarangsi T. The situation of alcohol consumption and its’ impacts in Thailand in B.E. 2556. Nonthaburi: The Graphico System; 2013.
Lekfueng N, Tharnpanich N, Tacharoen K, Wongwaisiriwatana S, Witworapong N. The situation of alcohol consumption in Northern Thailand 2015: Research Center for alcohol problems. Bangkok: Duen Tula Publishing House; 2015.
Chaisong S, Pakdeesettakul K, Thammarangsee T. Provincial alcohol report 2011. Nonthaburi: The Graphico System Publishing; 2013.
Babor T, Higgins-Biddle J, Saunders J, Monteriro M. The Alcohol Use Disorders Identification Test: guidelines for use in primary care. 2nd ed. Geneva: WHO; 2001.
Sun K, Ren M, Liu D, Wang C, Yang C, Yan L. Alcohol consumption and risk of metabolic syndrome: a metaanalysis of prospective studies. Clin Nutr 2014;33:596-602.
Tresserra-Rimbau A, Medina-Remón A, Lamuela-Raventós RM, Bulló M, Salas-Salvadó J, Corella D, et al. Moderate red wine consumption is associated with a lower prevalence of the metabolic syndrome in the PREDIMED population. Br J Nutr 2015;113(Suppl 2):S121-30.
Lerssrimongkol C, Angkurawaranon C, Thongtong P, Promkumton P, Kusirisin W. Prevalence of metabolic syndrome among healthy Thai adults at the Out-Patient Clinic of Family Medicine Department. Lanna Public Health J 2008;4:392-8.
World Health Organisation. Waist circumference and waisthip ratio: report of a WHO expert consultation [monograph on the Internet]. Geneva: WHO; 2011 [cited 2016 Jun 22]. Available from: https://www.who.int/publications/i/item/ 9789241501491
Lam DW, LeRoith D. Metabolic syndrome [monograph on the Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000 [cited 2019 Feb 11]. Available from: https://www.ncbi. nlm.nih.gov/books/NBK278936/
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome. AHA/NHLBI Scientific Statement. Circulation 2005;112:2735-45.
Thaikla K. Thai Standard Drinks Calculator version 1.0: Research Center for alcohol problems. Chiang Mai: Institute of Health Sciences, Chiang Mai University; 2010 [cited 2019 Feb 11]. Available from: https://nsbapp.com/dwbb/ ThaiDrink/
Wakabayashi M, McKetin R, Banwell C, Yiengprugsawan V, Kelly M, Seubsman SA, et al. Alcohol consumption patterns in Thailand and their relationship with non-communicable disease. BMC Public Health 2015;15:1297.
National Statistical Office Thailand. Executive Summary: The 2017 Survey on Health, Welfare, and food consumption behavior [monograph on the Internet]. Bangkok: National Statistical Office Thailand; 2017 [cited 2018 Nov 8]. Available from: http://www.nso.go.th/sites/2014
National Statistical Office Thailand. The smoking and drinking behavior survey 2017 [monograph on the Internet]. Bangkok: National Statistical Office Thailand; 2017 [cited 2020 Jun 6]. Available form: http://www.nso.go.th/sites/2014en/ Survey/social/health/SmokingDrinking/2017/Full%20Report. pdf
Bermudez V, Martinez MS, Chavez-Castillo M, Olivar LC, Morillo J, Mejias JC, et al. Relationship between alcohol consumption and components of the metabolic syndrome in adult population from Maracaibo City, Venezuela. Adv Prev Med 2015:352547.
Jin L, Huang Y, Bi Y, Zhao L, Xu M, Xu Y, et al. Association between alcohol consumption and metabolic syndrome in 19,215 middle-aged and elderly Chinese. Diabetes Res Clin Pract 2011;92:386-92.
Kabagambe EK, Baylin A, Ruiz-Narvaez E, Rimm EB, Campos H. Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica. Am J Clin Nutr 2005;82:1336-45.
Lee MY, Kim MY, Kim SY, Kim JH, Kim BH, Shin JY, et al. Association between alcohol intake amount and prevalence of metabolic syndrome in Korean rural male population. Diabetes Res Clin Pract 2010;88:196-202.
Baik I, Shin C. Prospective study of alcohol consumption and metabolic syndrome. Am J Clin Nutr 2008;87:1455-63.
Caton SJ, Ball M, Ahern A, Hetherington MM. Dose-dependent effects of alcohol on appetite and food intake. Physiol Behav 2004;81:51-8.
Klop B, do Rego AT, Cabezas MC. Alcohol and plasma triglycerides. Curr Opin Lipidol 2013;24:321-6.
Traversy G, Chaput JP. Alcohol consumption and obesity: an update. Current Obesity Reports 2015;4:122-30.
Suter PM. Is alcohol consumption a risk factor for weight gain and obesity?. Crit Rev Clin Lab Sci 2005;42:197-227.
Fan AZ, Russell M, Dorn J, Freudenheim JL, Nochajski T, Hovey K, et al. Lifetime alcohol drinking pattern is related to the prevalence of metabolic syndrome. The Western New York Health Study (WNYHS). Eur J Epidemiol 2006;21:129-38.
Husain K, Ansari RA, Ferder L. Alcohol-induced hypertension: Mechanism and prevention. World J Cardiol 2014;6:245-52.
Moreira LB, Fuchs FD, Moraes RS, Bredemeier M, Duncan BB. Alcohol intake and blood pressure: the importance of time elapsed since last drink. J Hypertens 1998;16:175-80.
Seppa K, Laippala P, Sillanaukee P. High diastolic blood pressure: common among women who are heavy drinkers. Alcohol Clin Exp Res 1996;20:47-51.
Dong-Qing Z, Chang-Quan H, Yan-Ling Z, Bi-Rong D, Qing-Xiu L. Cigarette smoking is associated with increased diastolic blood pressure among Chinese nonagenarians/ centenarians. Blood Press 2014;23:168-73.
Midha T, Lalchandani A, Nath B, Kumari R, Pandey U. Prevalence of isolated diastolic hypertension and associated risk factors among adults in Kanpur, India. Indian Heart J 2012; 64:374-9.
De Oliveira ESER, Foster D, McGee Harper M, Seidman CE, Smith JD, Breslow JL, et al. Alcohol consumption raises HDL cholesterol levels by increasing the transport rate of apolipoproteins A-I and A-II. Circulation 2000;102:2347-52.
Kralova Lesna I, Suchanek P, Stavek P, Poledne R. May alcohol-induced increase of HDL be considered as atheroprotective?. Physiol Res 2010;59:407-13.
Galan I, Valencia-Martin JL, Guallar-Castillon P, RodriguezArtalejo F. Alcohol drinking patterns and biomarkers of coronary risk in the Spanish population. Nutr Metab Cardiovasc Dis 2014;24:189-97.
Huang S, Li J, Shearer GC, Lichtenstein AH, Zheng X, Wu Y, et al. Longitudinal study of alcohol consumption and HDL concentrations: a community-based study. Am J Clin Nutr 2017;105:905-12.
Okamoto Y, Fujimori Y, Nakano H, Tsujii T. Role of the liver in alcohol-induced alteration of high-density lipoprotein metabolism. J Lab Clin Med 1988;111:482-5.
Ross R, Berentzen T, Bradshaw AJ, Janssen I, Kahn HS, Katzmarzyk PT, et al. Does the relationship between waist circumference, morbidity and mortality depend on measurement protocol for waist circumference?. Obes Rev 2008;9:312-25
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