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Home > Vol 41, No 1 (2023) > Tungsattayathitthan

Bilateral Orbital Inflammation Associated with COVID-19 Infection: A Case Report and Brief Review of the Literature

Usanee Tungsattayathitthan, Teechaya Nonboonyawat, Parinda Phinitkitanan, Nuttha Sanghan, Orapan Aryasit, Wantanee Sittivarakul

Abstract

A 31-year-old woman with no history of systemic autoimmune disease developed bilateral pain, redness, periorbital edema, and proptosis while being hospitalized for mild coronavirus disease 2019 (COVID-19) pneumonia. The onset of ocular symptoms occurred six days after systemic COVID-19 symptoms. Computed tomography examination of the orbit revealed diffuse inflammation involving multiple orbital structures. A complete systemic workup was performed to exclude other systemic inflammatory diseases. She was initially diagnosed with probable orbital cellulitis secondary to sinusitis. However, she did not improve with antibiotic therapy. Empirical administration of systemic corticosteroids led to a dramatic clinical response. The patient has been maintained on a gradual steroid taper without inflammation relapse. This article describes a potential causal association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and orbital inflammation. Ophthalmologists should be aware of this presentation when assessing patients with COVID-19 who present with orbital inflammatory symptoms.

 Keywords

autoinflammation; COVID-19; orbit; orbital inflammation; SARS-CoV-2

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References

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DOI: http://dx.doi.org/10.31584/jhsmr.2022884

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About The Authors

Usanee Tungsattayathitthan
Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110
Thailand

Teechaya Nonboonyawat
Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110
Thailand

Parinda Phinitkitanan
Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110
Thailand

Nuttha Sanghan
Department of Radiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110
Thailand

Orapan Aryasit
Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110
Thailand

Wantanee Sittivarakul
Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110
Thailand

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