Nutritional Status and Outcomes of Thai Elderly Patients Hospitalized with Heart Failure
Abstract
Objective: To assess the prevalence of undernourishment, nutritional status, and clinical outcomes among patients with heart failure admitted to Bangkok Heart Hospital using the Mini Nutritional Assessment-Short Form (MNA-SF).
Material and Methods: This cross-sectional retrospective study enrolled 361 patients hospitalized with heart failure in Bangkok Heart Hospital between January 2019 and December 2022. The MNA-SF was used as a screening scale to assess nutritional status. Clinical outcomes included length of stay, hospital-acquired infections, in-hospital mortality, unscheduled 30-day hospital readmission, and all-cause mortality within 180 days post-discharge.
Results: The study included 239 hospitalized patients with a median age of 80 years (interquartile range, IQR: 72.0-80.0); among them, there were 128 men. Most patients experienced heart failure with preserved ejection fraction. The prevalence of undernutrition was 61.1%, with a median length of stay of 8 days (IQR: 5.0–15.0). The median length of stay of the well-nourished patients (6 days, IQR: 4.0-11.5) was significantly lower than that of the undernourished patients (9 days, IQR: 6.0–15.0; p-value<0.01). In addition, the hospital-acquired infection rate was significantly higher in undernourished patients (43.8% and 16.1%; p-value<0.01). The unscheduled 30-day hospital readmission rate and mortality rate within 6 months post-discharge were significantly higher among undernourished patients than among well-nourished patients.
Conclusion: Undernutrition resulted in worse clinical outcomes, including prolonged hospital stay, hospital-acquired infections, unscheduled 30-day readmission, and a high mortality rate within 6 months post-discharge.
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Kałužna-Oleksy M, Krysztofiak H, Migaj J, Wleklik M, Dudek M, Uchmanowicz I, et al. Relationship between nutritional status and clinical and biochemical parameters in hospitalized patients with heart failure with reduced ejection fraction, with 1-year follow-up. Nutrients 2020;12:2330. doi: 10.3390/nu12082330.
Li H, Zhou P, Zhao Y, Ni H, Luo X, Li J. Prediction of all-cause mortality with malnutrition assessed by controlling nutritional status score in patients with heart failure: a systematic review and meta-analysis. Public Health Nutr 2021;25:1799-806.
Miao JP, Quan XQ, Zhang CT, Zhu H, Ye M, Shen LY, et al. Comparison of two malnutrition risk screening tools with nutritional biochemical parameters, BMI and length of stay in Chinese geriatric inpatients: a multicenter, cross-sectional study. BMJ Open 2019;9:e022993. doi: 10.1136/bmjopen-2018-022993.
Chuansangeam M, Wuthikraikun C, Supapueng O, Muangpaisan W. Prevalence and risk for malnutrition in older Thai people: a systematic review and meta-analysis. Asia Pac J Clin Nutr 2022;31:128-41.
Esteban-Fernández A, Villar-Taibo R, Alejo M, Arroyo D, Bonilla Palomas JL, Cachero M, et al. Diagnosis and management of malnutrition in patients with heart failure. J Clin Med 2023;12:3320. doi: 10.3390/jcm12093320.
Sze S, Pellicori P, Zhang J, Weston J, Clark AL. Agreement and classification performance of malnutrition tools in patients with chronic heart failure. Curr Dev Nutr 2020;4:nzaa071. doi: 10.1093/cdn/nzaa071.
Cederholm T, Barazzoni R, Austin P, Ballmer P, Biolo G, Bischoff SC, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr 2017;36:49–64.
Wleklik M, Uchmanowicz I, Jankowska-Polañska B, Andreae C, Regulska-Ilow B. The role of nutritional status in elderly patients with heart failure. J Nutr Health Aging 2018;22:581-8.
Tonet E, Campana R, Caglioni S, Gibiino F, Fiorio A, Chiaranda G, et al. Tools for the assessment of the malnutrition status and possible interventions in elderly with cardiovascular diseases. J Clin Med 2021;10:1508. doi: 10.3390/jcm10071508.
Joaquín C, Alonso N, Lupón J, de Antonio M, Domingo M, Moliner P, et al. A Mini nutritional assessment short form is a morbi-mortality predictor in outpatients with heart failure and mid-range left ventricular ejection fraction. Clin Nutr 2020;39:3395-401.
Osório AF, Ribeiro ÉCT, Parahiba SM, Forte GC, Clausell NO, et al. Prognostic value of nutritional screening tools in hospitalized patients with decompensated heart failure: a systematic review and meta-analysis. Nutr Res 2023;120:1-19. doi: 10.1016/j.nutres.2023.09.009.
McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 2021;42:3599-726. doi: 10.1093/eurheartj/ehab368.
Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Colvin MM, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the american college of cardiology/american heart association task force on clinical practice guidelines and the heart failure society of america. Circulation 2017;136:e137-61. doi: 10.1002/ejhf.2115.
Barbosa JS, Souza MFCd. Costa JO, Alves LVS, Oliveira LMSMd, Almeida RRd, et al. Assessment of malnutrition in heart failure and its relationship with clinical problems in Brazilian health services. Int J Environ Res Public Health 2022;19:10090. doi: 10.3390/ijerph191610090.
Maeda D, Dotare T, Matsue Y, Teramoto K, Sunayama T, Tromp J, et al. Blood pressure in heart failure management and prevention. Hypertens Res 2023;46:817-33.
Bhirommuang N, Komindr S, and Jayanama K. Impact of nutritional status on length of stay and hospital costs among patients admitted to a tertiary care hospital in Thailand. Asia Pac J Clin Nutr 2019;28:252-9. doi: 10.6133/apjcn.201906_28(2).0007.
Takeuchi S, Kohno T, Goda A, Shiraishi Y, Saji M, Nagatomo Y, et al. West Tokyo heart failure registry investigators. Malnutrition in real-world patients hospitalized for heart failure with preserved ejection fraction and its potential impact on generalizability of EMPEROR-Preserved trial. Int J Cardiol 2023;370:263-70.
Tackling G, Borhade MB. Hypertensive heart disease. Florida: StatPearls Publishing; 2023.
Seko Y, Kato T, Morimoto T, Yaku H, Inuzuka Y, Tamaki Y, et al. Association between body mass index and prognosis of patients hospitalized with heart failure. Sci Rep 2020;10:16663. doi: 10.1038/s41598-020-73640-w.
Nguyen HTT, Ha TTT, Tran HB, Nguyen DV, Pham HM, Tran PM, et al. Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study. Front Nutr 2023 Nov 30;10:1251601. doi: 10.3389/fnut.2023.1251601.
Zhu J, Liu Y, Liang H, Liu Q, Yao Z, He Y, et al. Analysis of factors associated with 6MWD among older patients with chronic heart failure. J Int Med Res 2023;51:03000605231166275. doi: 10.1177/03000605231166275.
Stewart S, Robertson C, Pan J, Kennedy S, Haahr L, Manoukian S, et al. Impact of healthcare-associated infection on length of stay. J Hosp Infect 2021;114:23-31.
Zhang X, Zhang X, Zhu Y, Tao J, Zhang Z, Zhang Y, et al. Predictive Value of Nutritional risk screening 2002 and mini nutritional assessment short form in mortality in Chinese hospitalized geriatric patients. Clin Interv Aging 2020;15:441-9.
Bonilla-Palomas JL, Gámez-López AL, Castillo-Domínguez JC, Moreno-Conde M, López Ibáñez MC, Alhambra Expósito R, et al. Nutritional intervention in malnourished hospitalized patients with heart failure. Arch Med Res 2016;47:535-40.
Sato Y, Kumada M, Kawai H, Motoyama S, Sarai M, Nakagawa T, et al. Geriatric nutritional risk index as readmission predictor in older adults with heart failure irrespective of ejection fraction. Fujita Med J 2023;9:211-7. doi: 10.20407/fmj.2022-028.
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