Gastric Schwannoma
Abstract
A gastric schwannoma is a rare primary spindle cell mesenchymal tumor of the digestive tract. Gastric schwannomas originate from Schwann cells of the peripheral nerves in the stomach. The majority of schwannomas are benign, slow growing tumors only a few of which develop into malignancies. Due to their indolent course, in most cases, gastric schwannomas are asymptomatic or discovered as an incidental finding on cross-sectional imaging or endoscopy. When symptomatic, the most common presenting symptoms are abdominal pain, upper gastrointestinal bleeding and intra- abdominal mass. Preoperatively, gastric schwannomas are difficult to differentiate from other mesenchymal tumors, such as gastrointestinal stroma or leiomyoma which develop from mesenchymal stem cells. The optimal management of the tumor is based on the symptoms of the patient, tumor size and histologic grading and the prognosis is excellent after complete surgical or endoscopic removal. Gastric schwannomas need multidisciplinary team management for definitive diagnosis and management, including specialists from gastroenterology, surgery, radiology and pathology.
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Lin CS, Hsu HS, Tsai CH, Li WY, Huang MH. Gastric schwannoma. J Chin Med Assoc 2004;67:583-6.
McNeer G, Pack GT. Neoplasms of the stomach. Philadephia: J.B. Lippincott; 1974.
Hou YY, Tan YS, Xu JF, Wang XN, Lu SH, Ji Y, et al. Schwannoma of the gastrointestinal tract: a clinicopathological, immunohisto- chemical and ultrastructural study of 33 cases. Histopathology 2006;48:536-45.
Daimaru Y, Kido H, Hashimoto H, Enjoji M. Benign schwannoma of the gastrointestinal tract: a clinicopathologic and immuno- histochemical study. Humpathol 1988;19:257-64.
Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal tumors (GISTs): a review. Eur J Cancer 2002;38:39-51.
Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohisto- chemical, and molecular genetic study of 1,765 cases with long-term follow-up. Am J Surg Pathol 2005;29:52–68.
Diaz ST, Hansson CM, de Bustos C, Mantripagada KK, Piotrowski A, Benetkiewicz M, et al. High-resolution array-CGH profiling of germline and tumor-specific copy number alterations on chromosome 22 in patients affected with schwannomas. Hum Genet 2005;118:35-44.
Lysandra V, Rebecca M, Jerzy L, Miettinen M. Gastric schwan- noma: a clinicopathologic study of 51 cases and critical review of the literature. Hum Pathol 2012;43:650-9.
Evans DG. Neurofibromatosis type 2 (NF2): a clinical and molecular review. Orphaned J Rare Dis 2009;4:16.
Agaimy A, Markl B, Kitz J, Wunsch PH, Arnholdt H, Fuzesi L, et al. Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphological variants. Virchows Arch 2010;456:411-22.
Agaimy A, Markl B, Kitz J. Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-assocated gastric schwannoma and unusual morphologic variants. Virchows Arch 2010;456:411-22.
Hong HS, Ha HK, Won HJ, Byun JH, Shin YM, Kim AY, et al.Gastric schwannoma: radiological features with endoscopic and pathological correlation. Clin Radiol 2008;63:536-42.
Takeda M, Amano Y, Machida T, Kato S, Naito Z, Kumita S. CT, MRI, and PET findings of gastric schwannoma. Jpn J Radiol 2012;30:602-5.
Yoon W, Paulson K, Mazzara P. Gastric schwannoma: a rare but important differential diagnosis of a gastric submucosal mass. Case Rep Surg 2012;2012:280982.
Hiroki S, Kitano M, Kudo M. Diagnosis of subepithelial tumors in the upper gastrointestinal tract by endoscopic ultrasono- graphy. World J Radiol 2010;28:289-97.
Zhong D, Wang C, Xu J, Chen MY, Cai JT. Endoscopic ultra- sound features of gastric schwannomas with radiological correlation: a case series report. World J Gastroenterol 2012; 18:7397-401.
Hwang JH, Rulyak SD, Kimmey MB. American gastroentero- logical association institute technical review on the management of gastric subepithelial masses. Gastroenterology 2006; 130:2217-28.
Mekky MA, Yamao K, Sawaki A, Mizuno N, Hara K, Nafeh MA, et al. Diagnosis utility of EUS-guided FNA in patients with gastric submucosal tumors. Gastrointest Endosc 2010;71: 913-9.
Sepe PS, Brugge WR. A guide for the diagnosis and management of gastrointestinal stromal cell tumors. Nat Rev Gastroenterol Hepatol 2009;6:363-71.
Kongkam P, Devereaux BM, Ponnudurai P, Rattanachu-ek T, Sahai AV, Gotoda T, et al. Endoscopic ultrasound forum summary from the Asian Pacific digestive week. Endosc Ultrasound 2013;2:43-60.
Bandoh T, Isoyama T, Toyoshima H. Submucosal tumors of the stomach: a study of 100 operative cases. Surgery 1993; 113:498-506.
Cai MY, Xu Jx, Zhou PH, XU MD, Chen SY, Hou J. Endoscopic resection for gastric schwannoma with long-term outcomes. Surg Endosc 2016;30:3994-4000.
Atmatzidis S, Chatzimavroudis G, Dragoumis D, Tsiaousis P, Patsas A, Atmatzidis K. Gastric schwannoma: a case report and literature review. Hipokratia 2012;16:280-2.
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